PT  - JOURNAL ARTICLE
AU  - Miles Wischnewski
AU  - Kathleen E. Mantell
AU  - Alexander Opitz
TI  - Identifying regions in prefrontal cortex related to working memory improvement: a novel meta-analytic method using electric field modeling
AID  - 10.1101/2021.03.11.435002
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.03.11.435002
4099  - http://biorxiv.org/content/early/2021/03/11/2021.03.11.435002.short
4100  - http://biorxiv.org/content/early/2021/03/11/2021.03.11.435002.full
AB  - Altering cortical activity using transcranial direct current stimulation (tDCS) has been shown to improve working memory (WM) performance. Due to large inter-experimental variability in the tDCS montage configuration and strength of induced electric fields, results have been mixed. Here, we present a novel meta-analytic method relating behavioral effect sizes to electric field strength to identify brain regions underlying largest tDCS-induced WM improvement. Simulations on 69 studies targeting left prefrontal cortex showed that tDCS electric field strength in lower dorsolateral prefrontal cortex (Brodmann area 45/47) relates most strongly to improved WM performance. This region explained 7.8% of variance, equaling a medium effect. A similar region was identified when correlating WM performance and electric field strength of right prefrontal tDCS studies (n = 18). Maximum electric field strength of five previously used tDCS configurations were outside of this location. We thus propose a new tDCS montage which maximizes the tDCS electric field strength in that brain region. Our findings can benefit future tDCS studies that aim to affect WM function.Highlights- We summarize the effect of 87 tDCS studies on working memory performance- We introduce a new meta-analytic method correlating tDCS electric fields and performance- tDCS-induced electric fields in lower DLPFC correlate significantly with improved working memory- The lower DLPFC was not maximally targeted by most tDCS montages and we provide an optimized montageCompeting Interest StatementThe authors have declared no competing interest.