RT Journal Article
SR Electronic
T1 Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.03.11.434829
DO 10.1101/2021.03.11.434829
A1 Xiao, Yan
A1 Hoodless, Laura J
A1 Petrucco, Luigi
A1 Portugues, Ruben
A1 Czopka, Tim
YR 2021
UL http://biorxiv.org/content/early/2021/03/12/2021.03.11.434829.abstract
AB Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity, and in consequence impaired visual acuity. Therefore, OPCs fine-tune neural circuit structure and function independently of their canonical role to make myelin.Competing Interest StatementThe authors have declared no competing interest.