RT Journal Article
SR Electronic
T1 Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.03.09.434621
DO 10.1101/2021.03.09.434621
A1 Anna K. Gillespie
A1 Daniela A. Astudillo Maya
A1 Eric L. Denovellis
A1 Daniel F. Liu
A1 David B. Kastner
A1 Michael E. Coulter
A1 Demetris K. Roumis
A1 Uri T. Eden
A1 Loren M. Frank
YR 2021
UL http://biorxiv.org/content/early/2021/03/24/2021.03.09.434621.abstract
AB Executing memory-guided behavior requires both the storage of information about experience and the later recall of that information to inform choices. Awake hippocampal replay, when hippocampal neural ensembles briefly reactivate a representation related to prior experience, has been proposed to critically contribute to these memory-related processes. However, it remains unclear whether awake replay contributes to memory function by promoting the storage of past experiences, by facilitating planning based on an evaluation of those experiences, or both. We designed a dynamic spatial task which promotes replay before a memory-based choice and assessed how the content of replay related to past and future behavior. We found that replay content was decoupled from subsequent choice and instead was enriched for representations of previously rewarded locations and places that had not been recently visited, indicating a role in memory storage rather than in directly guiding subsequent behavior.Competing Interest StatementThe authors have declared no competing interest.