PT  - JOURNAL ARTICLE
AU  - Adele Fanelli
AU  - Laura Ferlauto
AU  - Elodie Geneviève Zollinger
AU  - Olivier Brina
AU  - Philippe Reymond
AU  - Paolo Machi
AU  - Diego Ghezzi
TI  - Degradable endovascular neural interface for minimally invasive neural recording and stimulation
AID  - 10.1101/2021.03.24.436737
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.03.24.436737
4099  - http://biorxiv.org/content/early/2021/03/25/2021.03.24.436737.short
4100  - http://biorxiv.org/content/early/2021/03/25/2021.03.24.436737.full
AB  - Neural recording and stimulation have been widely used to mitigate traumatic injuries, neurodegenerative diseases or mental disorders. Most neural interfaces commonly require invasive surgery, potentially entailing both transient and permanent complications. A promising strategy designed to overcome these risks involves exploiting the cerebrovascular system as an access route to the neural tissue. Here we present a novel endovascular neural interface for neural recording and stimulation, fully polymeric and degradable. This concept might allow for better integration of the device in the body, reduced inflammatory reaction, the possibility of replacing the implant after degradation, and avoiding removal surgeries. The vasculature’s strategic distribution and the use of soft polymers for the device’s fabrication will permit targeting both the brain vasculature and the peripheral system. Therefore, this novel endovascular neural interface will broaden the range of applications from neurological diseases and mental disorders to bioelectronics medicine.Competing Interest StatementThe authors have declared no competing interest.