RT Journal Article
SR Electronic
T1 Degradable endovascular neural interface for minimally invasive neural recording and stimulation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.03.24.436737
DO 10.1101/2021.03.24.436737
A1 Adele Fanelli
A1 Laura Ferlauto
A1 Elodie Geneviève Zollinger
A1 Olivier Brina
A1 Philippe Reymond
A1 Paolo Machi
A1 Diego Ghezzi
YR 2021
UL http://biorxiv.org/content/early/2021/03/25/2021.03.24.436737.abstract
AB Neural recording and stimulation have been widely used to mitigate traumatic injuries, neurodegenerative diseases or mental disorders. Most neural interfaces commonly require invasive surgery, potentially entailing both transient and permanent complications. A promising strategy designed to overcome these risks involves exploiting the cerebrovascular system as an access route to the neural tissue. Here we present a novel endovascular neural interface for neural recording and stimulation, fully polymeric and degradable. This concept might allow for better integration of the device in the body, reduced inflammatory reaction, the possibility of replacing the implant after degradation, and avoiding removal surgeries. The vasculature’s strategic distribution and the use of soft polymers for the device’s fabrication will permit targeting both the brain vasculature and the peripheral system. Therefore, this novel endovascular neural interface will broaden the range of applications from neurological diseases and mental disorders to bioelectronics medicine.Competing Interest StatementThe authors have declared no competing interest.