TY - JOUR T1 - Predictors of zoonotic potential in helminths JF - bioRxiv DO - 10.1101/2021.03.28.437423 SP - 2021.03.28.437423 AU - Ania A. Majewska AU - Tao Huang AU - Barbara Han AU - John M. Drake Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/03/29/2021.03.28.437423.abstract N2 - Helminths are parasites that cause disease at considerable cost to public health and present a risk for emergence as novel human infections. Although recent research has elucidated characteristics conferring a propensity to emergence in other parasite groups (e.g. viruses), the understanding of factors associated with zoonotic potential in helminths remains poor. We applied an investigator-directed learning algorithm to a global dataset of mammal helminth traits to identify factors contributing to spillover of helminths from wild animal hosts into humans. We characterized parasite traits that distinguish between zoonotic and non-zoonotic species with greater than 88% accuracy. Results suggest that helminth traits relating to transmission (e.g. definitive and intermediate hosts) and geography (e.g. distribution) are more important to predicting zoonotic species than morphological or epidemiological traits. Whether or not a helminth causes infection in companion animals (cats and dogs) is the most important predictor of propensity to cause human infection. Finally, we identified helminth species with high modeled propensity to cause zoonosis (over 70%) that have not previously been deemed to be of risk. This work highlights the importance of prioritizing studies on the transmission of helminths that infect pets and points to the risks incurred by close associations with these animals.Competing Interest StatementThe authors have declared no competing interest. ER -