PT - JOURNAL ARTICLE AU - Vaser, Robert AU - Sović, Ivan AU - Nagarajan, Niranjan AU - Šikić, Mile TI - Fast and accurate <em>de novo</em> genome assembly from long uncorrected reads AID - 10.1101/068122 DP - 2016 Jan 01 TA - bioRxiv PG - 068122 4099 - http://biorxiv.org/content/early/2016/08/05/068122.short 4100 - http://biorxiv.org/content/early/2016/08/05/068122.full AB - The assembly of long reads from Pacific Biosciences and Oxford Nanopore Technologies typically requires resource intensive error correction and consensus generation steps to obtain high quality assemblies. We show that the error correction step can be omitted and high quality consensus sequences can be generated efficiently with a SIMD accelerated, partial order alignment based stand-alone consensus module called Racon. Based on tests with PacBio and Oxford Nanopore datasets we show that Racon coupled with Miniasm enables consensus genomes with similar or better quality than state-of-the-art methods while being an order of magnitude faster.Racon is available open source under the MIT license at https://github.com/isovic/racon.git.