TY - JOUR T1 - Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells JF - bioRxiv DO - 10.1101/2021.03.29.437400 SP - 2021.03.29.437400 AU - Hygor P. M. Melo AU - F. Raquel Maia AU - André S. Nunes AU - Rui L. Reis AU - Joaquim M. Oliveira AU - Nuno A. M. Araújo Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/03/29/2021.03.29.437400.abstract N2 - The collective dynamics of cells on surfaces and interfaces poses technological and theoretical challenges in the study of morphogenesis, tissue engineering, and cancer. Different mechanisms are at play, including, cell-cell adhesion, cell motility, and proliferation. However, the relative importance of each one is elusive. Here, experiments with a culture of glioblastoma multiforme cells on a substrate are combined with in silico modeling to infer the rate of each mechanism. By parametrizing these rates, the time-dependence of the spatial correlation observed experimentally is reproduced. The obtained results suggest a reduction in cell-cell adhesion with the density of cells. The reason for such reduction and possible implications for the collective dynamics of cancer cells are discussed.Competing Interest StatementThe authors have declared no competing interest. ER -