RT Journal Article
SR Electronic
T1 Cytoarchitectonic similarity is a wiring principle of the human connectome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 068254
DO 10.1101/068254
A1 Alexandros Goulas
A1 René Werner
A1 Sarah F Beul
A1 Dennis Säring
A1 Martijn van den Heuvel
A1 Lazaros C Triarhou
A1 Claus C Hilgetag
YR 2016
UL http://biorxiv.org/content/early/2016/08/06/068254.abstract
AB Understanding the wiring diagram of the human cerebral cortex is a fundamental challenge in neuroscience. Elemental aspects of its organization remain elusive. Here we examine which structural traits of cortical regions, particularly their cytoarchitecture and thickness, relate to the existence and strength of inter-regional connections. We use the architecture data from the classic work of von Economo and Koskinas and state-of-the-art diffusion-based connectivity data from the Human Connectome Project. Our results reveal a prominent role of the cytoarchitectonic similarity of supragranular layers for predicting the existence and strength of connections. In contrast, cortical thickness similarity was not related to the existence or strength of connections. These results are in line with findings for non-human mammalian cerebral cortices, suggesting overarching wiring principles of the mammalian cerebral cortex. The results invite hypotheses about evolutionary conserved neurobiological mechanisms that give rise to the relation of cytoarchitecture and connectivity in the human cerebral cortex.