PT  - JOURNAL ARTICLE
AU  - Sebastian H. Bitzenhofer
AU  - Jastyn A. Pöpplau
AU  - Mattia Chini
AU  - Annette Marquardt
AU  - Ileana L. Hanganu-Opatz
TI  - Activity-dependent maturation of prefrontal gamma oscillations sculpts cognitive performance
AID  - 10.1101/558957
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 558957
4099  - http://biorxiv.org/content/early/2019/02/22/558957.short
4100  - http://biorxiv.org/content/early/2019/02/22/558957.full
AB  - Gamma oscillations are the neural network attribute of cognitive processing. They emerge early in life, yet their contribution to cortical circuit formation is unknown. We show that layer 2/3 pyramidal neurons entrain mouse prefrontal cortex in fast oscillations with increasing frequency across development. Chronic boosting of fast oscillations at neonatal age reversibly alters neuronal morphology, but cause permanent circuity dysfunction and impairs recognition memory and social interactions later in life.One sentence summary Fast oscillatory activity in layer 2/3 sculpts the maturation of prefrontal cortex and cognitive performance.