RT Journal Article
SR Electronic
T1 Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.04.05.437224
DO 10.1101/2021.04.05.437224
A1 Cesheng Li
A1 Ding Yu
A1 Xiao Wu
A1 Hong Liang
A1 Zhijun Zhou
A1 Yong Xie
A1 Taojing Li
A1 Junzheng Wu
A1 Fengping Lu
A1 Lu Feng
A1 Min Mao
A1 Lianzhen Lin
A1 Huanhuan Guo
A1 Shenglan Yue
A1 Feifei Wang
A1 Yan Peng
A1 Yong Hu
A1 Zejun Wang
A1 Jianhong Yu
A1 Yong Zhang
A1 Jia Lu
A1 Haoran Ning
A1 Huichuan Yang
A1 Daoxing Fu
A1 Yanlin He
A1 Dongbo Zhou
A1 Tao Du
A1 Kai Duan
A1 Demei Dong
A1 Kun Deng
A1 Xia Zou
A1 Ya Zhang
A1 Rong Zhou
A1 Yang Gao
A1 Xinxin Zhang
A1 Xiaoming Yang
YR 2021
UL http://biorxiv.org/content/early/2021/04/05/2021.04.05.437224.abstract
AB To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conducted a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and tested specific antibody response. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. RBD-IgG kinetics displayed a gradually downward trend, the titer started to stabilize after 9 months and decreased by 68.1% compared with the 1st month. Moreover, male plasma donors produced more RBD-IgG than female plasma donors and patient age positively correlated with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers was also identified. This study is essential for understanding SARS-CoV-2-induced immune memory to develop vaccine and therapeutics.Competing Interest StatementThe authors have declared no competing interest.