PT  - JOURNAL ARTICLE
AU  - Wei Liu
AU  - Yingjie Shi
AU  - James N. Cousins
AU  - Nils Kohn
AU  - Guillén Fernández
TI  - Hippocampal-medial prefrontal event segmentation and integration contribute to episodic memory formation
AID  - 10.1101/2020.03.14.990002
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2020.03.14.990002
4099  - http://biorxiv.org/content/early/2021/04/06/2020.03.14.990002.short
4100  - http://biorxiv.org/content/early/2021/04/06/2020.03.14.990002.full
AB  - How do we encode our continuous life experiences for later retrieval? Theories of event segmentation and integration suggest that the hippocampus binds separately represented events into an ordered narrative. Using a functional Magnetic Resonance Imaging (fMRI) movie watching-recall dataset, we quantified two types of neural similarities (i.e., activation pattern similarity and within-region voxel-based connectivity pattern similarity) between separate events during movie watching and related them to subsequent retrieval of events as well as retrieval of sequential order. We demonstrate that compared to forgotten events, successfully remembered events are associate with distinct activation patterns in the hippocampus and medial prefrontal cortex. By contrast, similar connectivity patterns between events are associated with memory formation and are also relevant for retaining events in the correct order. We applied the same approaches to an independent movie watching fMRI dataset as validation and highlighted again the role of hippocampal activation pattern and connectivity pattern in memory formation. We propose that distinct activation patterns represent neural segmentation of events while similar connectivity patterns encode context information, and therefore integrate events into a narrative. Our results provide novel evidence for the role of hippocampal-medial prefrontal event segmentation and integration in episodic memory formation of real-life experience.Competing Interest StatementThe authors have declared no competing interest.