PT  - JOURNAL ARTICLE
AU  - ER Buch
AU  - L Claudino
AU  - R Quentin
AU  - M Bönstrup
AU  - LG Cohen
TI  - Consolidation of human skill linked to waking hippocampo-neocortical replay
AID  - 10.1101/2021.04.07.438819
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.04.07.438819
4099  - http://biorxiv.org/content/early/2021/04/07/2021.04.07.438819.short
4100  - http://biorxiv.org/content/early/2021/04/07/2021.04.07.438819.full
AB  - The introduction of rest intervals interspersed with practice strengthens wakeful consolidation of skill. The mechanisms by which the brain binds discrete action representations into consolidated, highly temporally-resolved skill sequences during waking rest are not known. To address this question, we recorded magnetoencephalography (MEG) during acquisition and rapid consolidation of a sequential motor skill. We report the presence of highly prominent, fast waking neural replay during the same rest periods in which rapid consolidation occurs. The observed replay was temporally compressed by approximately 20x relative to the acquired skill, occurred in both forward and reverse directions, was selective for the trained sequence and predicted the magnitude of skill consolidation. Replay representations extended beyond the hippocampus and entrorhinal cortex to the contralateral sensorimotor cortex. These results document the presence of robust hippocampo-neocortical replay supporting rapid wakeful consolidation of skill.Competing Interest StatementThe authors have declared no competing interest.