RT Journal Article SR Electronic T1 Non-invasive real-time access to the output of the spinal cord via a wrist wearable interface JF bioRxiv FD Cold Spring Harbor Laboratory SP 2021.04.06.438640 DO 10.1101/2021.04.06.438640 A1 Irene Mendez A1 Deren Y. Barsakcioglu A1 Ivan Vujaklija A1 Daniel Z. Wetmore A1 Dario Farina YR 2021 UL http://biorxiv.org/content/early/2021/04/08/2021.04.06.438640.abstract AB Despite the promising features of neural interfaces, their trade-off between information transfer and invasiveness has limited translation and viability outside research settings. Here, we present a non-invasive neural interface that provides access to spinal motoneuron activities from a sensor band at the wrist. The interface decodes electric signals present at the tendon endings of the forearm muscles by using a model of signal generation and deconvolution. First, we evaluated the reliability of the interface to detect motoneuron firings, and thereafter we used the decoded neural activity for the prediction of finger movements in offline and real-time conditions. The results showed that motoneuron activity decoded from the wrist accurately predicted individual and combined finger commands and therefore allowed for highly accurate real-time control. These findings demonstrate the feasibility of a wearable, non-invasive, neural interface at the wrist for precise real-time control based on the output of the spinal cord.Competing Interest StatementD.Z.W. is a Research Scientist at Facebook Reality Labs with salary and equity compensation from Facebook. D.F. is Scientific Advisor for Facebook Reality Labs with compensation for this service from Facebook. D.Y.B and D.F. are inventors in a patent (Neural Interface. UK Patent application no. GB1813762.0. August 23, 2018) and patent application (Neural interface. UK Patent application no. GB2014671.8. September 17, 2020) related to the methods and applications of this work.