PT  - JOURNAL ARTICLE
AU  - Stephanie Cerceo Page
AU  - Srinidhi Rao Sripathy
AU  - Federica Farinelli
AU  - Zengyou Ye
AU  - Yanhong Wang
AU  - Daniel J Hiler
AU  - Elizabeth A Pattie
AU  - Claudia V Nguyen
AU  - Madhavi Tippani
AU  - Rebecca L. Moses
AU  - Huei-Ying Chen
AU  - Matthew Nguyen Tran
AU  - Nicholas J Eagles
AU  - Joshua M Stolz
AU  - Joseph L Catallini II
AU  - Olivia R Soudry
AU  - Dwight Dickinson
AU  - Karen F Berman
AU  - Jose A Apud
AU  - Daniel R Weinberger
AU  - Keri Martinowich
AU  - Andrew E Jaffe
AU  - Richard E Straub
AU  - Brady J Maher
TI  - Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance
AID  - 10.1101/2021.04.08.437289
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.04.08.437289
4099  - http://biorxiv.org/content/early/2021/04/10/2021.04.08.437289.short
4100  - http://biorxiv.org/content/early/2021/04/10/2021.04.08.437289.full
AB  - Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to model basic cellular aspects of neuropsychiatric disorders, but the relationship between the emergent phenotypes and the clinical characteristics of donor individuals has been unclear. We analyzed RNA expression and indices of cellular function in hiPSC-derived neural progenitors and cortical neurons generated from 13 individuals with high polygenic risk scores (PRS) for schizophrenia and a clinical diagnosis of schizophrenia, along with 15 neurotypical individuals with low PRS. We identified electrophysiological measures associated with diagnosis that implicated altered Na+ channel function and GABA-ergic neurotransmission. Importantly, electrophysiological measures predicted cardinal clinical and cognitive features found in these schizophrenia patients. The identification of basic neuronal physiological properties related to core clinical characteristics of illness is a potentially critical step in generating leads for novel therapeutics.Competing Interest StatementThe authors have declared no competing interest.