PT  - JOURNAL ARTICLE
AU  - Lucas C. Pantaleão
AU  - Isabella Inzani
AU  - Samuel Furse
AU  - Elena Loche
AU  - Antonia Hufnagel
AU  - Thomas Ashmore
AU  - Heather L. Blackmore
AU  - Benjamin Jenkins
AU  - Asha A. M. Carpenter
AU  - Ania Wilczynska
AU  - Martin Bushell
AU  - Albert Koulman
AU  - Denise S. Fernandez-Twinn
AU  - Susan E. Ozanne
TI  - Maternal diet-induced obesity during pregnancy alters lipid supply to fetuses and changes the cardiac tissue lipidome in a sex-dependent manner
AID  - 10.1101/2021.04.12.439435
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.04.12.439435
4099  - http://biorxiv.org/content/early/2021/04/12/2021.04.12.439435.short
4100  - http://biorxiv.org/content/early/2021/04/12/2021.04.12.439435.full
AB  - Maternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in fetuses of diet-induced obese pregnant mice and established the changes in lipid abundance and fetal cardiac transcriptomics. We used untargeted and targeted lipidomics and transcriptomics to define changes in the serum and cardiac lipid composition and fatty acid metabolism in male and female fetuses. From these analyses we observed: (1) maternal obesity affects the maternal and fetal serum lipidome distinctly; (2) female heart lipidomes are more sensitive to maternal obesity than male fetuses; (3) changes in lipid supply might contribute to early expression of lipolytic genes in mouse hearts exposed to maternal obesity. These results highlight the existence of sexually dimorphic responses of the fetal heart to the same in utero obesogenic environment and identify lipids species that might mediate programming of cardiovascular health.Competing Interest StatementThe authors have declared no competing interest.