PT  - JOURNAL ARTICLE
AU  - Shannon E. Ellis
AU  - Simone Gupta
AU  - Anna Moes
AU  - Andrew B. West
AU  - Dan E. Arking
TI  - Exaggerated CpH Methylation in the Autism-Affected Brain
AID  - 10.1101/069120
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 069120
4099  - http://biorxiv.org/content/early/2016/08/11/069120.short
4100  - http://biorxiv.org/content/early/2016/08/11/069120.full
AB  - The etiology of autism, a complex neurodevelopmental disorder, remains largely unexplained. Here, we explore the role of CpG and CpH (H=A, C, or T) methylation within autism-affected cortical brain tissue. While no individual site of methylation was significantly associated with autism after multi-test correction, methylated CpH di-nucleotides were markedly enriched in autism-affected brains (~2-fold enrichment at p <0.05 cut-off, p=0.002). These results further implicate epigenetic alterations in pathobiological mechanisms that underlie autism.