RT Journal Article
SR Electronic
T1 Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.28.358556
DO 10.1101/2020.10.28.358556
A1 Muhammad Arif
A1 Martina Klevstig
A1 Rui Benfeitas
A1 Stephen Doran
A1 Hasan Turkez
A1 Mathias Uhlén
A1 Maryam Clausen
A1 Johannes Wikström
A1 Damla Etal
A1 Cheng Zhang
A1 Malin Levin
A1 Adil Mardinoglu
A1 Jan Boren
YR 2021
UL http://biorxiv.org/content/early/2021/04/18/2020.10.28.358556.abstract
AB Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in a mouse model of MI (induced by ligating the left ascending coronary artery) and sham-operated mice. We performed a genome-wide transcriptomic analysis on tissue samples obtained 6- and 24-hours post MI or sham operation. By generating tissue-specific biological networks, we observed: (1) dysregulation in multiple biological processes (including immune system, mitochondrial dysfunction, fatty-acid beta-oxidation, and RNA and protein processing) across multiple tissues post MI; and (2) tissue-specific dysregulation in biological processes in liver and heart post MI. Finally, we validated our findings in two independent MI cohorts. Overall, our integrative analysis highlighted both common and specific biological responses to MI across a range of metabolically active tissues.Competing Interest StatementJW, MC, DE are employees at AstraZeneca. The other authors declare no conflict of interest.