TY - JOUR T1 - Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior JF - bioRxiv DO - 10.1101/2021.04.19.440478 SP - 2021.04.19.440478 AU - R. de Vlaming AU - Eric A.W. Slob AU - Philip R. Jansen AU - Alain Dagher AU - Philipp D. Koellinger AU - Patrick J.F. Groenen AU - Cornelius A. Rietveld Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/04/19/2021.04.19.440478.abstract N2 - Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce multivariate genomic-relatedness restricted maximum likelihood (MGREML) and provide estimates of the heritability of grey-matter volume in 74 regions of interest (ROIs) in the brain. We map genetic correlations between these ROIs and health-relevant behavioral outcomes including intelligence. We find four genetically distinct clusters in the brain that are aligned with standard anatomical subdivision in neuroscience. Behavioral traits have distinct genetic correlations with brain morphology which suggests trait-specific relevance of ROIs.Competing Interest StatementThe authors have declared no competing interest. ER -