RT Journal Article
SR Electronic
T1 Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.04.19.440478
DO 10.1101/2021.04.19.440478
A1 R. de Vlaming
A1 Eric A.W. Slob
A1 Philip R. Jansen
A1 Alain Dagher
A1 Philipp D. Koellinger
A1 Patrick J.F. Groenen
A1 Cornelius A. Rietveld
YR 2021
UL http://biorxiv.org/content/early/2021/04/19/2021.04.19.440478.abstract
AB Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce multivariate genomic-relatedness restricted maximum likelihood (MGREML) and provide estimates of the heritability of grey-matter volume in 74 regions of interest (ROIs) in the brain. We map genetic correlations between these ROIs and health-relevant behavioral outcomes including intelligence. We find four genetically distinct clusters in the brain that are aligned with standard anatomical subdivision in neuroscience. Behavioral traits have distinct genetic correlations with brain morphology which suggests trait-specific relevance of ROIs.Competing Interest StatementThe authors have declared no competing interest.