TY - JOUR T1 - Scalable total-evidence inference from molecular and continuous characters in a Bayesian framework JF - bioRxiv DO - 10.1101/2021.04.21.440863 SP - 2021.04.21.440863 AU - Rong Zhang AU - Alexei J. Drummond AU - Fábio K. Mendes Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/04/22/2021.04.21.440863.abstract N2 - Time-scaled phylogenetic trees are both an ultimate goal of evolutionary biology and a necessary ingredient in comparative studies. While accumulating genomic data has moved the field closer to a full description of the tree of life, the relative timing of certain evolutionary events remains challenging even when this data is abundant, and absolute timing is impossible without external information such as fossil ages and morphology. The field of phylogenetics lacks efficient tools integrating probabilistic models for these kinds of data into unified frameworks for estimating phylogenies. Here, we implement, benchmark and validate popular phylogenetic models for the study of paleontological and neontological continuous trait data, incorporating these models into the BEAST2 platform. Our methods scale well with number of taxa and of characters. We tip-date and estimate the topology of a phylogeny of Carnivora, comparing results from different configurations of integrative models capable of leveraging ages, as well as molecular and continuous morphological data from living and extinct species. Our results illustrate and advance the paradigm of Bayesian, probabilistic total evidence, in which explanatory models are fully defined, and inferential uncertainty in all their dimensions is accounted for.Competing Interest StatementThe authors have declared no competing interest. ER -