RT Journal Article
SR Electronic
T1 Adaptive ecological processes and metabolic independence drive microbial colonization and resilience in the human gut
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.03.02.433653
DO 10.1101/2021.03.02.433653
A1 Andrea R. Watson
A1 Jessika Füssel
A1 Iva Veseli
A1 Johanna Zaal DeLongchamp
A1 Marisela Silva
A1 Florian Trigodet
A1 Karen Lolans
A1 Alon Shaiber
A1 Emily Fogarty
A1 Joseph M. Runde
A1 Christopher Quince
A1 Michael K. Yu
A1 Arda Söylev
A1 Hilary G. Morrison
A1 Sonny T.M. Lee
A1 Dina Kao
A1 David T. Rubin
A1 Bana Jabri
A1 Thomas Louie
A1 A. Murat Eren
YR 2021
UL http://biorxiv.org/content/early/2021/04/22/2021.03.02.433653.abstract
AB A detailed understanding of human gut microbial ecology is essential to engineer effective microbial therapeutics and to model microbial community assembly in health and disease. However, establishing generalizable insights into the functional determinants of microbial fitness in the gut has been a formidable challenge. Here we employ fecal microbiota transplantation (FMT) as an in natura experimental model to identify determinants of microbial colonization and resilience. Our findings reveal adaptive ecological processes that favor high-fitness populations with higher metabolic competence as the main driver of microbial colonization outcomes after FMT. We further show that while healthy individuals harbor both low-fitness and high-fitness populations, individuals with inflammatory bowel disease are typically depleted of low-fitness populations. These results offer a model to explain why common yet typically rare members of healthy guts can dominate under inflammatory conditions without any need for them to be causally associated with, or contribute to, such disease states.Competing Interest StatementThe authors have declared no competing interest.