PT  - JOURNAL ARTICLE
AU  - Elizabeth J. Brant
AU  - Edward A. Rietman
AU  - Giannoula Lakka Klement
AU  - Marco Cavaglia
AU  - Jack A. Tuszynski
TI  - Personalized Therapy Design for Systemic <em>Lupus Erythematosus</em> Based on the Analysis of Protein-Protein Interaction Networks
AID  - 10.1101/559740
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 559740
4099  - http://biorxiv.org/content/early/2019/02/24/559740.short
4100  - http://biorxiv.org/content/early/2019/02/24/559740.full
AB  - We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associated protein-protein interaction networks for each of the 291 patients whose samples were used to provide the molecular data. We have concluded that among the many proteins that appear to play critical roles in this pathology, most of them are either ribosomal proteins, ubiquitination pathway proteins or heat shock proteins. We propose some of the proteins identified in this study to be considered for drug targeting.