RT Journal Article SR Electronic T1 Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks JF bioRxiv FD Cold Spring Harbor Laboratory SP 559740 DO 10.1101/559740 A1 Elizabeth J. Brant A1 Edward A. Rietman A1 Giannoula Lakka Klement A1 Marco Cavaglia A1 Jack A. Tuszynski YR 2019 UL http://biorxiv.org/content/early/2019/02/24/559740.abstract AB We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associated protein-protein interaction networks for each of the 291 patients whose samples were used to provide the molecular data. We have concluded that among the many proteins that appear to play critical roles in this pathology, most of them are either ribosomal proteins, ubiquitination pathway proteins or heat shock proteins. We propose some of the proteins identified in this study to be considered for drug targeting.