RT Journal Article
SR Electronic
T1 The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.04.26.441470
DO 10.1101/2021.04.26.441470
A1 Matthieu P. Platre
A1 Santosh B. Satbhai
A1 Lukas Brent
A1 Matias F. Gleason
A1 Magali Grison
A1 Marie Glavier
A1 Ling Zhang
A1 Min Cao
A1 Christophe Gaillochet
A1 Christian Goeschl
A1 Marco Giovannetti
A1 Balaji Enugutti
A1 Marcel von Reth
A1 Ruben Alcázar
A1 Jane E. Parker
A1 Grégory Vert
A1 Emmanuelle Bayer
A1 Wolfgang Busch
YR 2021
UL http://biorxiv.org/content/early/2021/04/26/2021.04.26.441470.abstract
AB Iron is critical for host-pathogen interactions. While pathogens seek to scavenge iron to spread, the host aims at decreasing iron availability to reduce pathogen virulence. Thus, iron sensing and homeostasis are of particular importance to prevent host infection and part of nutritional immunity. While the link between iron homeostasis and immunity pathways is well established in plants, how iron levels are sensed and integrated with immune response pathways remain unknown. We identified a receptor kinase, SRF3 coordinating root growth, iron homeostasis and immunity pathways via regulation of callose synthase activity. These processes are modulated by iron levels and rely on SRF3 extracellular and kinase domain which tune its accumulation and partitioning at the cell surface. Mimicking bacterial elicitation with the flagellin peptide flg22 phenocopies SRF3 regulation upon low iron levels and subsequent SRF3-dependent responses. We propose that SRF3 is part of nutritional immunity responses involved in sensing external iron levels.Competing Interest StatementThe authors have declared no competing interest.