RT Journal Article
SR Electronic
T1 Iota-carrageenan prevents the replication of SARS-CoV-2 on an in vitro respiratory epithelium model
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.04.27.441512
DO 10.1101/2021.04.27.441512
A1 Varese, Augusto
A1 Ceballos, Ana
A1 Palacios, Carlos
A1 Figueroa, Juan Manuel
A1 Dugour, Andrea Vanesa
YR 2021
UL http://biorxiv.org/content/early/2021/04/27/2021.04.27.441512.abstract
AB There are, except for remdesivir, no approved antivirals for the treatment or prevention of SARS-CoV-2 infections. Iota-carrageenan formulated into a nasal spray has already been proven safe and effective in viral respiratory infections. We explored this antiviral activity in Calu-3, a human respiratory model cell line. A formula of iota-carrageenan and sodium chloride, as a nasal spray, already approved for human use, effectively inhibited SARS-CoV-2 infection in vitro, providing a more substantial reference for further clinical studies or developments.Competing Interest StatementThe authors have declared no competing interest.