PT  - JOURNAL ARTICLE
AU  - T.C. Lacy
AU  - P.A. Robinson
AU  - K.M. Aquino
AU  - J.C. Pang
TI  - Cortical Depth-Dependent Modeling of Visual Hemodynamic Responses
AID  - 10.1101/2020.03.16.993154
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2020.03.16.993154
4099  - http://biorxiv.org/content/early/2021/04/28/2020.03.16.993154.short
4100  - http://biorxiv.org/content/early/2021/04/28/2020.03.16.993154.full
AB  - A physiologically based three-dimensional (3D) hemodynamic model is used to predict the experimentally observed blood oxygen level dependent (BOLD) responses versus the cortical depth induced by visual stimuli. Prior 2D approximations are relaxed in order to analyze 3D blood flow dynamics as a function of cortical depth. Comparison of the predictions with experimental data for typical stimuli demonstrates that the full 3D model matches at least as well as previous approaches while requiring significantly fewer assumptions and model parameters (e.g., there is no more need to define depth-specific parameter values for spatial spreading, peak amplitude, and hemodynamic velocity).Competing Interest StatementThe authors have declared no competing interest.