PT  - JOURNAL ARTICLE
AU  - Cohn-Sheehy, Brendan I.
AU  - Delarazan, Angelique I.
AU  - Reagh, Zachariah M.
AU  - Crivelli-Decker, Jordan E.
AU  - Kim, Kamin
AU  - Barnett, Alexander J.
AU  - Zacks, Jeffrey M.
AU  - Ranganath, Charan
TI  - Building bridges: the hippocampus constructs narrative memories across distant events
AID  - 10.1101/2020.12.11.422162
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2020.12.11.422162
4099  - http://biorxiv.org/content/early/2021/04/29/2020.12.11.422162.short
4100  - http://biorxiv.org/content/early/2021/04/29/2020.12.11.422162.full
AB  - Life’s events are scattered throughout time, yet we often recall different events in the context of an integrated narrative. Prior research suggests that the hippocampus, which supports memory for past events, can sometimes support integration of overlapping associations or separate events, but the conditions which lead to hippocampus-dependent memory integration are unclear. We used functional brain imaging to test whether the ability to form a larger narrative (narrative coherence) drives hippocampal memory integration. During encoding of fictional stories, the hippocampus supported patterns of activity, including activity at boundaries between events, which were more similar between distant events that formed one coherent narrative, compared with events taken from unrelated narratives. Twenty-four hours later, the hippocampus preferentially supported detailed recall of coherent narrative events, through reinstatement of hippocampal activity patterns from encoding. These findings reveal a key function of the hippocampus: the dynamic integration of events into a narrative structure for memory.Competing Interest StatementThe authors have declared no competing interest.