PT  - JOURNAL ARTICLE
AU  - Alireza Nikbakht
AU  - Jafar Javadpour
AU  - M. Reza Naimi-Jamal
AU  - Hamidreza Rezaie
TI  - Fabrication and Evaluation of Mechanical and Tribological Properties of ultra-high-molecular-weight polyethylene-based Nanocomposites Reinforced with Hydroxyapatite, Zirconia and Multi-walled Carbon Nanotubes
AID  - 10.1101/2021.05.03.442451
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.05.03.442451
4099  - http://biorxiv.org/content/early/2021/05/03/2021.05.03.442451.short
4100  - http://biorxiv.org/content/early/2021/05/03/2021.05.03.442451.full
AB  - The unique properties of ultra-high-molecular-weight polyethylene (UHMWPE) have made composites based on this polymer the gold standard choice for articulating surfaces used in arthroplasty. However, wear debris released by prosthesis is still a major concern of the implants. In this study, we address the urgent need to revisit the current methodologies used in designing these biomaterials by fabricating UHMWPE-based nanocomposite with Hydroxyapatite (HA), Multi-walled Carbon Nanotubes (MWCNTs), and Zirconia as additives. We investigated how different combinations of these additives impact the nanocomposites’ hardness, plasticity index (PI), and friction coefficient. Our results show a constant increase in hardness by increasing Zirconia. The MTT assay test and Scanning Electron Microscopy (SEM) demonstrated an increase in cell attachment and cell viability. Examining various additives’ amounts, we can further explore the possibility of reaching an optimum proportion of the ingredients. Compared with other UHMWPE-based nanocomposites (UHMWPE-HA-MWCNT’s), the fabricated nanocomposite shows an improvement in tribological properties.Competing Interest StatementThe authors have declared no competing interest.