RT Journal Article
SR Electronic
T1 Possible role of accessory proteins in the viral replication for the 20I/501Y.V1 (B.1.1.7) SARS-CoV-2 variant
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.04.30.442222
DO 10.1101/2021.04.30.442222
A1 Dimpal A. Nyayanit
A1 Prasad Sarkale
A1 Anita Shete-Aich
A1 Abhinendra Kumar
A1 Savita Patil
A1 Triparna Majumdar
A1 Shreekant Baradkar
A1 Pranita Gawande
A1 Sreelekshmy Mohandas
A1 Pragya D Yadav
YR 2021
UL http://biorxiv.org/content/early/2021/05/03/2021.04.30.442222.abstract
AB The study investigates the replication cycle and transcriptional pattern of the B.1.1.7 variant. It was observed that the B.1.1.7 variant required a longer maturation time. The transcriptional response demonstrated higher expression of ORF6 and ORF8 compared to nucleocapsid transcript till the eclipse period which might influence higher viral replication. The number of infectious viruses titer is higher in the B.1.1.7, despite a lesser copy number than B.1, indicating higher infectivity.Competing Interest StatementThe authors have declared no competing interest.