RT Journal Article
SR Electronic
T1 Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.05.06.443017
DO 10.1101/2021.05.06.443017
A1 Xiaomin Liu
A1 Xin Tong
A1 Jie Zhu
A1 Liu Tian
A1 Zhuye Jie
A1 Yuanqiang Zou
A1 Xiaoqian Lin
A1 Hewei Liang
A1 Wenxi Li
A1 Yanmei Ju
A1 Youwen Qin
A1 Leying Zou
A1 Haorong Lu
A1 Xun Xu
A1 Huanming Yang
A1 Jian Wang
A1 Yang Zong
A1 Weibin Liu
A1 Yong Hou
A1 Shida Zhu
A1 Xin Jin
A1 Huijue Jia
A1 Tao Zhang
YR 2021
UL http://biorxiv.org/content/early/2021/05/07/2021.05.06.443017.abstract
AB The oral microbiota contains billions of microbial cells, which could contribute to diseases in a number of body sites. Challenged by eating, drinking and dental hygiene on a daily basis, the oral microbiota is regarded as highly dynamic. Here, we report significant human genomic associations with the oral metagenome from more than 1,915 individuals, for both the tongue dorsum and saliva. Five genetic loci, APPL2, SLC2A9 and MGST1 associated with tongue dorsum, LOC102723769-OR11H1-POTEH and MTRNR2L1-LOC105371703-MIR4522 associated with salivary microbial features, reached study-wide significance (p < 3.16 × 10−11). Further analyses confirmed 6 genome-wide significant loci shared between tongue dorsum and saliva. For example, the dental caries pathogen Prevotella melaninogenica associated with MARK2-RCOR2; the periodontitis bacteria Treponema associated with CCL26-CCL24 and Porphyromonas associated with CSMD1 at both niches. Human genetics account for at least 10% of oral microbiome differences between individuals. Machine learning models showed that polygenetic risk score dominated over oral microbiome in predicting predisposing risk of dental diseases such as dental calculus and gingival bleeding. These findings indicate that human genetic differences are one explanation for a stable or recurrent oral microbiome in each individual.Competing Interest StatementThe authors have declared no competing interest.