%0 Journal Article %A Szu-Hsien Sam Wu %A Réka Szép-Bakonyi %A Heetak Lee %A Gabriele Colozza %A Ayse Boese %A Krista Rene Gert %A Natalia Hallay %A Jihoon Kim %A Yi Zhu %A Sandra Pilat-Carotta %A Hans-Christian Theussl %A Andrea Pauli %A Bon-Kyoung Koo %T SCON - A Short Conditional intrON for conditional knockout with one-step zygote injection %D 2021 %R 10.1101/2021.05.09.443220 %J bioRxiv %P 2021.05.09.443220 %X The generation of conditional alleles using CRISPR technology is still challenging. Here, we introduce a Short Conditional intrON (SCON, 189 bp) that enables rapid generation of conditional alleles via one-step zygote injection. SCON has conditional intronic function in various vertebrate species and its target insertion is as simple as CRISPR/Cas9-mediated gene tagging.Competing Interest StatementThe authors have declared no competing interest. %U https://www.biorxiv.org/content/biorxiv/early/2021/05/10/2021.05.09.443220.full.pdf