TY - JOUR T1 - mRNA-decapping associated DcpS enzyme controls critical steps of neuronal development JF - bioRxiv DO - 10.1101/2021.05.10.443481 SP - 2021.05.10.443481 AU - Iva Salamon AU - Geeta Palsule AU - Xiaobing Luo AU - Alfonso Roque AU - Shawn Tucai AU - Ishan Khosla AU - Nicole Volk AU - Wendy Liu AU - Huijuan Cui AU - Valentina Dal Pozzo AU - Petronio Zalamea AU - Xinfu Jiao AU - Gabriella D’Arcangelo AU - Ronald P Hart AU - Mladen-Roko Rasin AU - Megerditch Kiledjian Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/05/11/2021.05.10.443481.abstract N2 - Homozygous mutations in the gene encoding the scavenger mRNA-decapping enzyme, DcpS, have been shown to underlie developmental delay and intellectual disability. Intellectual disability is associated with both abnormal neocortical development and mRNA metabolism. However, the role of DcpS and its scavenger decapping activity in neuronal development is unknown. Here, we show that human neurons derived from patients with a DcpS mutation have compromised differentiation and neurite outgrowth. Moreover, in the developing mouse neocortex, DcpS is required for the radial migration, polarity, neurite outgrowth and identity of developing glutamatergic neurons. Collectively, these findings demonstrate that the scavenger mRNA decapping activity contributes to multiple pivotal roles in neural development, and further corroborate that mRNA metabolism and neocortical pathologies are associated with intellectual disability.Competing Interest StatementThe authors have declared no competing interest. ER -