TY - JOUR T1 - Segregation and integration of the functional connectome in neurodevelopmentally ‘at risk’ children JF - bioRxiv DO - 10.1101/2021.05.11.443579 SP - 2021.05.11.443579 AU - J. S. Jones AU - the CALM Team AU - D. E. Astle Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/05/12/2021.05.11.443579.abstract N2 - Functional connectivity within and between Intrinsic Connectivity Networks (ICNs) transforms over development and supports high order cognitive functions. But how variable is this process, and does it diverge with altered cognitive developmental trajectories? We investigated age-related changes in integration and segregation within and between ICNs in neurodevelopmentally ‘at-risk’ children, identified by practitioners as experiencing cognitive difficulties in attention, learning, language, or memory. In our analysis we used performance on a battery of 10 cognitive tasks, alongside resting-state functional Magnetic Resonance Imaging in 175 at-risk children and 62 comparison children aged 5-16. We observed significant age-by-group interactions in functional connectivity between two network pairs. Integration between the ventral attention and visual networks and segregation of the limbic and fronto-parietal networks increased with age in our comparison sample, relative to at-risk children. Furthermore, functional connectivity between the ventral attention and visual networks in comparison children significantly mediated age-related improvements in executive function, compared to at-risk children. We conclude that integration between ICNs show divergent neurodevelopmental trends in the broad population of children experiencing cognitive difficulties, and that these differences in functional brain organisation may partly explain the pervasive cognitive difficulties within this group over childhood and adolescence.Research HighlightsWe investigated functional brain organisation and its development in 175 children who experience neurodevelopmental difficulties in cognition and behaviour, relative to a comparison sample (n=62)We replicated common neurodevelopmental trends across the samples: functional connectivity increased within Intrinsic Connectivity Networks and the default-mode network increasingly segregated with ageNeurodevelopmentally at-risk children also showed different age-related changes in functional connectivity between the ventral attention and visual networks and between the fronto-parietal and limbic networksFurthermore, the integration between the ventral attention and visual networks in comparison children mediated age-related changes in cognition, relative to at-risk childrenCompeting Interest StatementThe authors have declared no competing interest. ER -