RT Journal Article
SR Electronic
T1 Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 559393
DO 10.1101/559393
A1 Raymond Noordam
A1 Maxime M Bos
A1 Heming Wang
A1 Thomas W Winkler
A1 Amy R Bentley
A1 Tuomas O. Kilpeläinen
A1 Paul S de Vries
A1 Yun Ju Sung
A1 Karen Schwander
A1 Brian E Cade
A1 Alisa Manning
A1 Hugues Aschard
A1 Michael R Brown
A1 Han Chen
A1 Nora Franceschini
A1 Solomon K Musani
A1 Melissa Richard
A1 Dina Vojinovic
A1 Stella Aslibekyan
A1 Traci M Bartz
A1 Lisa de las Fuentes
A1 Mary Feitosa
A1 Andrea R Horimoto
A1 Marjan Ilkov
A1 Minjung Kho
A1 Aldi Kraja
A1 Changwei Li
A1 Elise Lim
A1 Yongmei Liu
A1 Dennis O Mook-Kanamori
A1 Tuomo Rankinen
A1 Salman M Tajuddin
A1 Ashley van der Spek
A1 Zhe Wang
A1 Jonathan Marten
A1 Vincent Laville
A1 Maris Alver
A1 Evangelos Evangelou
A1 Maria E Graff
A1 Meian He
A1 Brigitte Kühnel
A1 Leo-Pekka Lyytikäinen
A1 Pedro Marques-Vidal
A1 Ilja M Nolte
A1 Nicholette D Palmer
A1 Rainer Rauramaa
A1 Xiao-Ou Shu
A1 Harold Snieder
A1 Stefan Weiss
A1 Wanqing Wen
A1 Lisa R Yanek
A1 Correa Adolfo
A1 Christie Ballantyne
A1 Larry Bielak
A1 Nienke R Biermasz
A1 Eric Boerwinkle
A1 Niki Dimou
A1 Gudny Eiriksdottir
A1 Chuan Gao
A1 Sina A Gharib
A1 Daniel J Gottlieb
A1 José Haba-Rubio
A1 Tamara B Harris
A1 Sami Heikkinen
A1 Raphaël Heinzer
A1 James E Hixson
A1 Georg Homuth
A1 M Arfan Ikram
A1 Pirjo Komulainen
A1 Jose E Krieger
A1 Jiwon Lee
A1 Jingmin Liu
A1 Kurt K Lohman
A1 Annemarie I Luik
A1 Reedik Mägi
A1 Lisa W Martin
A1 Thomas Meitinger
A1 Andres Metspalu
A1 Yuri Milaneschi
A1 Mike A Nalls
A1 Jeff O’Connell
A1 Annette Peters
A1 Patricia Peyser
A1 Olli T Raitakari
A1 Alex P Reiner
A1 Patrick CN Rensen
A1 Treva K Rice
A1 Stephen S Rich
A1 Till Roenneberg
A1 Jerome I Rotter
A1 Pamela J Schreiner
A1 James Shikany
A1 Stephen S Sidney
A1 Mario Sims
A1 Colleen M Sitlani
A1 Tamar Sofer
A1 Konstantin Strauch
A1 Morris A Swertz
A1 Kent D Taylor
A1 André G Uitterlinden
A1 Cornelia M van Duijn
A1 Henry Völzke
A1 Melanie Waldenberger
A1 Robert B Wallance
A1 Ko Willems van Dijk
A1 Caizheng Yu
A1 Alan B Zonderman
A1 Diane M Becker
A1 Paul Elliott
A1 Tõnu Esko
A1 Christian Gieger
A1 Hans J Grabe
A1 Timo A Lakka
A1 Terho Lehtimäki
A1 Lifelines Cohort Study
A1 Kari E North
A1 Brenda WJH Penninx
A1 Peter Vollenweider
A1 Lynne E Wagenknecht
A1 Tangchun Wu
A1 Yong-Bing Xiang
A1 Wei Zheng
A1 Donna K Arnett
A1 Claude Bouchard
A1 Michele K Evans
A1 Vilmundur Gudnason
A1 Sharon Kardia
A1 Tanika N Kelly
A1 Stephen B Kritchevsky
A1 Ruth JF Loos
A1 Alexandre C Pereira
A1 Mike Province
A1 Bruce M Psaty
A1 Charles Rotimi
A1 Xiaofeng Zhu
A1 Najaf Amin
A1 L Adrienne Cupples
A1 Myriam Fornage
A1 Ervin F Fox
A1 Xiuqing Guo
A1 W James Gauderman
A1 Kenneth Rice
A1 Charles Kooperberg
A1 Patricia B Munroe
A1 Ching-Ti Liu
A1 Alanna C Morrison
A1 Dabeeru C Rao
A1 Diana van Heemst
A1 Susan Redline
YR 2019
UL http://biorxiv.org/content/early/2019/02/25/559393.abstract
AB Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To provide new insights in the biology of sleep-associated adverse lipid profile, we conducted multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identified 49 novel lipid loci, and 10 additional novel lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identified new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The novel gene-sleep interactions had a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explained 4.25% of the variance in triglyceride concentration. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.