RT Journal Article SR Electronic T1 LaminaRGeneVis: a tool to visualize gene expression across the laminar architecture of the human neocortex JF bioRxiv FD Cold Spring Harbor Laboratory SP 2021.05.12.443851 DO 10.1101/2021.05.12.443851 A1 Ethan Kim A1 Derek Howard A1 Yuxiao Chen A1 Shreejoy J. Tripathy A1 Leon French YR 2021 UL http://biorxiv.org/content/early/2021/05/14/2021.05.12.443851.abstract AB Application of RNA sequencing has enabled the characterization of genome-wide gene expression in the human brain, including distinct layers of the neocortex. Neuroanatomically, the molecular patterns that underlie the laminar organization of the neocortex can help link structure to circuitry and function. To advance our understanding of cortical architecture, we created LaminaRGeneVis, a web application that displays across-layer cortical gene expression from multiple datasets. These datasets were collected using bulk, single-nucleus, and spatial RNA sequencing methodologies and these data were harmonized to facilitate comparisons between datasets. The online resource facilitates single- and multi-gene analyses by providing figures and statistics for user-friendly assessment of laminar gene expression patterns in the adult human neocortex.Availability and implementation LaminaRGeneVis is available at https://ethanhkim.shinyapps.io/laminargenevis. The source code and data is accessible at https://github.com/ethanhkim/laminargenevis.Competing Interest StatementThe authors have declared no competing interest.