RT Journal Article
SR Electronic
T1 Neuro-musculoskeletal Upper Limb in-silico as virtual patient
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.05.16.444298
DO 10.1101/2021.05.16.444298
A1 Mallampalli Kapardi
A1 Madhav Vinodh Pithapuram
A1 Yashaswini Mandayam Rangayyan
A1 Raghu Sesha Iyengar
A1 Avinash Kumar Singh
A1 Sirisha Sripada
A1 Mohan Raghavan
YR 2021
UL http://biorxiv.org/content/early/2021/05/17/2021.05.16.444298.abstract
AB Virtual patients and physiologies allow experimentation, design, and early-stage clinical trials in-silico. Virtual patient technology for human movement systems that encompasses musculoskeleton and its neural control are few and far in between. In this work, we present one such neuro-musculoskeletal upper limb in-silico model. This upper limb is both modular in architecture and generates movement as an emergent phenomenon out of a multiscale co-simulation of spinal cord neural control and musculoskeletal dynamics. It is developed on the NEUROiD movement simulation platform that enables a co-simulation of popular neural simulator NEURON and the musculoskeletal simulator OpenSim. In this work, we describe the design and development of the upper limb in a modular fashion, while reusing existing models and modules. We further characterize and demonstrate the use of this model in generating a range of commonly observed movements by means of a spatio temporal stimulation pattern delivered to the cervical spinal cord. We believe this work enables a first and small step towards an in-silico paradigms for understanding upper limb movement, disease pathology, medication, and rehabilitation.Competing Interest StatementThe authors have declared no competing interest.