RT Journal Article
SR Electronic
T1 Reduced cortico-muscular beta coupling in Parkinson’s disease predicts motor impairment
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.05.15.444289
DO 10.1101/2021.05.15.444289
A1 Nahid Zokaei
A1 Andrew J Quinn
A1 Michele T Hu
A1 Masud Husain
A1 Freek van Ede
A1 Anna Christina Nobre
YR 2021
UL http://biorxiv.org/content/early/2021/05/17/2021.05.15.444289.abstract
AB Long-range communication through the motor system is thought to be facilitated by phase coupling between neural activity in the 15-30 Hz beta range. During periods of sustained muscle contraction (grip), such coupling is manifest between motor cortex and the contralateral forearm muscles – measured as the cortico-muscular coherence (CMC). We examined alterations in CMC in individuals with Parkinson’s disease (PD), while equating grip strength between individuals with PD (off their medication) and healthy control participants. We show a marked reduction in beta CMC in the PD group, even though the grip strength was comparable between the two groups. Moreover, the reduced CMC was related to motor symptoms, so that individuals with lower CMC also displayed worse motor symptoms. These findings highlight the CMC as a simple, effective, and clinically relevant neural marker of PD pathology, with the potential to aid monitoring of disease progression and the efficacy of novel treatments for PD.Competing Interest StatementThe authors have declared no competing interest.