TY - JOUR T1 - Predicting behavior through dynamic modes in resting-state fMRI data JF - bioRxiv DO - 10.1101/2021.05.22.445226 SP - 2021.05.22.445226 AU - Shigeyuki Ikeda AU - Koki Kawano AU - Soichi Watanabe AU - Okito Yamashita AU - Yoshinobu Kawahara Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/05/23/2021.05.22.445226.abstract N2 - Dynamic properties of resting-state functional connectivity (FC) provide rich information on brainbehavior relationships. Dynamic mode decomposition (DMD) has been used as a method to characterize FC dynamics. However, it remains unclear whether dynamic modes (DMs), spatial-temporal coherent patterns computed by DMD, provide information about individual behavioral differences. This study established a methodological approach to predict individual differences in behavior using DMs. Furthermore, we investigated the contribution of DMs within each of seven specific frequency bands (0-0.1,…,0.6–0.7 Hz) for prediction. To validate our approach, we confirmed whether each of 59 behavioral measures could be predicted by performing multivariate pattern analysis on a gram matrix, which was created using subject-specific DMs computed from resting-state functional magnetic resonance imaging (rs-fMRI) data of individuals. The prediction was successful, and DMD outperformed temporal independent component analysis, a conventional data decomposition method for extracting spatial activity patterns. Most of the behavioral measures that showed significant prediction accuracies in a permutation test were cognitive-behavioral measures. Our results suggested that DMs within frequency bands <0.2 Hz primarily contributed to prediction. In addition, we found that DMs <0.2 Hz had spatial structures similar to several common resting-state networks. We demonstrated the effectiveness of DMs, indicating that DMD is a key approach for extracting spatiotemporal features from rs-fMRI data.Competing Interest StatementThe authors have declared no competing interest. ER -