RT Journal Article
SR Electronic
T1 Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.05.26.445845
DO 10.1101/2021.05.26.445845
A1 Cigdem Gelegen
A1 Diana Cash
A1 Katarina Ilic
A1 Millie Sander
A1 Eugene Kim
A1 Camilla Simmons
A1 Michel Bernanos
A1 Joana Lama
A1 Karen Randall
A1 Jonathan T. Brown
A1 Svjetlana Kalanj-Bognar
A1 Samuel Cooke
A1 K Ray Chaudhuri
A1 Clive Ballard
A1 Paul Francis
A1 Ivana Rosenzweig
YR 2021
UL http://biorxiv.org/content/early/2021/05/27/2021.05.26.445845.abstract
AB Rapid eye movement (REM) sleep behaviour disorder (RBD) is a rare parasomnia that may predict the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.Competing Interest StatementThe authors have declared no competing interest.