TY - JOUR T1 - Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder JF - bioRxiv DO - 10.1101/2021.05.26.445845 SP - 2021.05.26.445845 AU - Cigdem Gelegen AU - Diana Cash AU - Katarina Ilic AU - Millie Sander AU - Eugene Kim AU - Camilla Simmons AU - Michel Bernanos AU - Joana Lama AU - Karen Randall AU - Jonathan T. Brown AU - Svjetlana Kalanj-Bognar AU - Samuel Cooke AU - K Ray Chaudhuri AU - Clive Ballard AU - Paul Francis AU - Ivana Rosenzweig Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/05/27/2021.05.26.445845.abstract N2 - Rapid eye movement (REM) sleep behaviour disorder (RBD) is a rare parasomnia that may predict the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.Competing Interest StatementThe authors have declared no competing interest. ER -