PT  - JOURNAL ARTICLE
AU  - Renzo Mancuso
AU  - Johanna Van Den Daele
AU  - Nicola Fattorelli
AU  - Leen Wolfs
AU  - Sriram Balusu
AU  - Oliver Burton
AU  - Annerieke Sierksma
AU  - Yannick Fourne
AU  - Suresh Poovathingal
AU  - Amaia Arranz-Mendiguren
AU  - Carlo Sala Frigerio
AU  - Christel Claes
AU  - Lutgarde Serneels
AU  - Tom Theys
AU  - V. Hugh Perry
AU  - Catherine Verfaillie
AU  - Mark Fiers
AU  - Bart De Strooper
TI  - Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer’s Disease
AID  - 10.1101/562561
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 562561
4099  - http://biorxiv.org/content/early/2019/02/27/562561.short
4100  - http://biorxiv.org/content/early/2019/02/27/562561.full
AB  - Genetics highlight the central role of microglia in Alzheimer’s disease but at least 36% of AD-risk genes lack good mouse orthologues. Here, we show that embryonic stem cell (ESC)-derived human microglia successfully engraft the mouse brain and recapitulate transcriptionally primary human microglia derived from human surgical samples. Upon exposure to oligomeric Aβ a wide range of AD-risk genes are expressed that are not readily studied in current mouse models for AD. This work provides a unique humanized animal model that will allow elucidating the role of genetic risk in the pathogenesis of AD.