RT Journal Article
SR Electronic
T1 Real-time individual benefit from social interactions before and during the lockdown: The crucial role of personality, neurobiology and genes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.06.02.446719
DO 10.1101/2021.06.02.446719
A1 Maximilian Monninger
A1 Pascal-M. Aggensteiner
A1 Tania M. Pollok
A1 Iris Reinhard
A1 Alisha S.M. Hall
A1 Lea Zillich
A1 Fabian Streit
A1 Stephanie-H. Witt
A1 Markus Reichert
A1 Ulrich Ebner-Priemer
A1 Andreas Meyer-Lindenberg
A1 Heike Tost
A1 Daniel Brandeis
A1 Tobias Banaschewski
A1 Nathalie E. Holz
YR 2021
UL http://biorxiv.org/content/early/2021/06/03/2021.06.02.446719.abstract
AB Background: Social integration is a major resilience factor for staying healthy. However, the COVID-19-pandemic led to unprecedented restrictions in social life. The consequences of these social lockdowns on momentary well-being are yet not fully understood.Method: We investigated the individual affective benefit from social interactions in a longitudinal birth cohort study. We used two real-time, real-life ecological momentary assessments once before and once during the initial lockdown of the pandemic (N~6800 total observations) to determine the protective role of social interactions on well-being. Moreover, we used a multimethod approach combining the ecological assessment data with individual risk and resilience factors to analyze the moderating mechanisms of personality, neurobiology and genes.Results: Social contacts were linked to higher positive affect both during normal times and during the COVID-19 pandemic, highlighting the beneficial role of social embedding. Moreover, this relationship was moderated by amygdala volume, neuroticism and polygenic risk for schizophrenia. In detail, participants with a larger left amygdala volume and higher trait neuroticism exhibited an affective benefit from more social interactions prior to the pandemic. This pattern changed during the pandemic with participants with smaller amygdala volumes and lower neurotic traits showing a social affective gain during the pandemic. Moreover, participants with low genetic risk for schizophrenia showed an affective benefit from social interactions irrespective of the time point.Conclusion: Our results highlight the protective role of social integration on momentary well-being. Thereby, we offer new insights into how this relationship is differently affected by a person’s, neurobiology, personality, and genes under adverse circumstances.Competing Interest StatementT.B. served in an advisory or consultancy role for Actelion, Hexal Pharma, Lilly, Lundbeck, Medice, Novartis and Shire. He received conference support or speaker's fees from Lilly, Medice, Novartis and Shire. He has been involved in clinical trials conducted by Shire and Viforpharma. He received royalties from Hogrefe, Kohlhammer, CIP Medien and Oxford University Press. D.B. serves as an unpaid scientific consultant for an EU funded neurofeedback trial unrelated to the present work. U.E.P. reports consultancy for Boehringer Ingelheim. A.M.L. has received consultant fees from the American Association for the Advancement of Science, Atheneum Partners, Blueprint Partnership, Boehringer Ingelheim, Daimler und Benz Stiftung, Elsevier, F. Hoffmann La Roche, ICARE Schizophrenia, K. G. Jebsen Foundation, L.E.K Consulting, Lundbeck International Foundation (LINF), R. Adamczak, Roche Pharma, Science Foundation, Sumitomo Dainippon Pharma, Synapsis Foundation Alzheimer Research Switzerland, System Analytics, and has received lectures fees including travel fees from Boehringer Ingelheim, Fama Public Relations, Institut d'investigacions Biomediques August Pi i Sunyer (IDIBAPS), Janssen Cilag, Klinikum Christophsbad, Goeppingen, Lilly Deutschland, Luzerner Psychiatrie, LVR Klinikum Duesseldorf, LWL Psychiatrie Verbund Westfalen-Lippe, Otsuka Pharmaceuticals, Reunions i Ciencia S. L., Spanish Society of Psychiatry, Suedwestrundfunk Fernsehen, Stern TV, and Vitos Klinikum Kurhessen. All other authors report no biomedical financial interests or potential conflicts of interest.