RT Journal Article
SR Electronic
T1 Genomic inference of a human super bottleneck in Mid-Pleistocene transition
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.05.16.444351
DO 10.1101/2021.05.16.444351
A1 Wangjie Hu
A1 Ziqian Hao
A1 Pengyuan Du
A1 Fabio Di Vincenzo
A1 Giorgio Manzi
A1 Yi-Hsuan Pan
A1 Haipeng Li
YR 2021
UL http://biorxiv.org/content/early/2021/06/08/2021.05.16.444351.abstract
AB The demographic history is a foundation of human evolutionary studies. We developed the fast infinitesimal time coalescent (FitCoal) process, which allows the accurate calculation of the composite likelihood of a site frequency spectrum and provides the precise inference of demographic history. Genomic analysis showed that African populations have passed through a population super bottleneck, a small effective size of approximately 1,280 breeding individuals between 930 and 813 thousand years ago. This time interval coincides with a gap in the human fossil record in Africa and possibly marks the origin of the Homo heidelbergensis. Further modelling analysis confirmed the existence of the super bottleneck in non-African populations. Our results provide new insights into human evolution during the Mid-Pleistocene.One-Sentence Summary A new method for demographic history inference and a human super bottleneck possibly marking the origin of H. heidelbergensisCompeting Interest StatementThe authors have declared no competing interest.