RT Journal Article
SR Electronic
T1 The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.06.08.447431
DO 10.1101/2021.06.08.447431
A1 Niklas Mejhert
A1 Katlyn R. Gabriel
A1 Natalie Krahmer
A1 Leena Kuruvilla
A1 Chandramohan Chitraju
A1 Sebastian Boland
A1 Dong-Keun Jang
A1 Marcin von Grotthuss
A1 Maria C. Costanzo
A1 Jason Flannick
A1 Noël P. Burtt
A1 Robert V. Farese, Jr.
A1 Tobias C. Walther
YR 2021
UL http://biorxiv.org/content/early/2021/06/09/2021.06.08.447431.abstract
AB Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid storage, such as atherosclerosis, obesity, type 2 diabetes mellitus, and hepatic steatosis. Consequently, there is an increasing need for a resource that combines large datasets from systematic analyses of LD biology. Here we integrate high-confidence, systematically generated data on studies of LDs in the framework of an online platform named the Lipid Droplet Knowledge Portal. This scalable and interactive portal includes comprehensive datasets, across a variety of cell types, for LD biology, including transcriptional profiles of induced lipid storage, organellar proteomics, genome-wide screen phenotypes, and ties to human genetics. This new resource is a powerful platform that can be utilized to uncover new determinants of lipid storage.HIGHLIGHTS■ The LD-Portal is a resource combining datasets from systematic analyses in LD biology■ The LD-Portal allows users to query genetic, proteomic, and phenotypic aspects of LD biology■ The LD-Portal can be used to discover new facets of lipid storage and LD biology■ A crucial function of MSRB3 is uncovered in cholesterol ester storage in LDsCompeting Interest StatementThe authors have declared no competing interest.