RT Journal Article
SR Electronic
T1 Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.06.09.447677
DO 10.1101/2021.06.09.447677
A1 Lea L. Backhausen
A1 Juliane H. Fröhner
A1 Hervé Lemaître
A1 Eric Artiges
A1 Marie-Laure Palillère Martinot
A1 Megan M. Herting
A1 Fabio Sticca
A1 Tobias Banaschewski
A1 Gareth J. Barker
A1 Arun L.W. Bokde
A1 Sylvane Desrivières
A1 Herta Flor
A1 Antoine Grigis
A1 Hugh Garavan
A1 Penny Gowland
A1 Andreas Heinz
A1 Rüdiger Brühl
A1 Frauke Nees
A1 Dimitri Papadopoulos-Orfanos
A1 Luise Poustka
A1 Sarah Hohmann
A1 Lauren Robinson
A1 Henrik Walter
A1 Jeanne Winterer
A1 Robert Whelan
A1 Gunter Schumann
A1 Jean-Luc Martinot
A1 Michael N. Smolka
A1 Nora C. Vetter
A1 the IMAGEN Consortium
YR 2021
UL http://biorxiv.org/content/early/2021/06/10/2021.06.09.447677.abstract
AB Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age-related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls.Competing Interest StatementDr Banaschewski served in an advisory or consultancy role for ADHS digital, Infectopharm, Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Roche, and Takeda. He received conference support or speakers fee by Medice and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press. The present work is unrelated to the above grants and relationships. Dr Barker has received honoraria from General Electric Healthcare for teaching on scanner programming courses. Dr Poustka served in an advisory or consultancy role for Roche and Viforpharm and received speakers fee by Shire. She received royalties from Hogrefe, Kohlhammer and Schattauer. The present work is unrelated to the above grants and relationships. The other authors report no biomedical financial interests or potential conflicts of interest.