PT  - JOURNAL ARTICLE
AU  - Rodrigo Tapia
AU  - Bárbara Brito
AU  - Marco Saavedra
AU  - Juan Mena
AU  - Tamara García-Salum
AU  - Raveen Rathnasinghe
AU  - Gonzalo Barriga
AU  - Karla Tapia
AU  - Victoria García
AU  - Sergio Bucarey
AU  - Yunho Jang
AU  - David Wentworth
AU  - Montserrat Torremorell
AU  - Víctor Neira
AU  - Rafael A. Medina
TI  - Identification of novel human derived influenza viruses in pigs with zoonotic potential
AID  - 10.1101/2021.06.08.447649
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.06.08.447649
4099  - http://biorxiv.org/content/early/2021/06/10/2021.06.08.447649.short
4100  - http://biorxiv.org/content/early/2021/06/10/2021.06.08.447649.full
AB  - In 2009, a novel swine influenza A virus (IAV) emerged causing a global pandemic that highlighted the role of swine as a reservoir. To date, there is limited information about swine IAV circulating in Latin America. We identified two swine H1N2 and one divergent swine H3N2 viruses that co-circulated in Chilean swine together with the 2009 H1N1 pandemic strain (A(H1N1)pdm09). Phylogenetic analysis revealed several human-to-swine IAV introductions occurring as early as the mid-1980s, and since 2009, several introductions of the A(H1N1)pdm09 strain. Antigenic cartography confirmed that these viruses were antigenically unique and identified drifted variants within the clusters. Human sera from the Chilean general population showed an age dependent mid to low-level antibody mediated protection against swine H1N2 and A(H1N1)pdm09-like viruses and a poor protection against the swine H3N2 virus, highlighting the zoonotic potential of this strain. Our results underscore the epidemiological importance of studying swine IAV in Latin America for epidemic and pandemic preparedness.