RT Journal Article
SR Electronic
T1 Identification of novel human derived influenza viruses in pigs with zoonotic potential
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.06.08.447649
DO 10.1101/2021.06.08.447649
A1 Rodrigo Tapia
A1 Bárbara Brito
A1 Marco Saavedra
A1 Juan Mena
A1 Tamara García-Salum
A1 Raveen Rathnasinghe
A1 Gonzalo Barriga
A1 Karla Tapia
A1 Victoria García
A1 Sergio Bucarey
A1 Yunho Jang
A1 David Wentworth
A1 Montserrat Torremorell
A1 Víctor Neira
A1 Rafael A. Medina
YR 2021
UL http://biorxiv.org/content/early/2021/06/10/2021.06.08.447649.abstract
AB In 2009, a novel swine influenza A virus (IAV) emerged causing a global pandemic that highlighted the role of swine as a reservoir. To date, there is limited information about swine IAV circulating in Latin America. We identified two swine H1N2 and one divergent swine H3N2 viruses that co-circulated in Chilean swine together with the 2009 H1N1 pandemic strain (A(H1N1)pdm09). Phylogenetic analysis revealed several human-to-swine IAV introductions occurring as early as the mid-1980s, and since 2009, several introductions of the A(H1N1)pdm09 strain. Antigenic cartography confirmed that these viruses were antigenically unique and identified drifted variants within the clusters. Human sera from the Chilean general population showed an age dependent mid to low-level antibody mediated protection against swine H1N2 and A(H1N1)pdm09-like viruses and a poor protection against the swine H3N2 virus, highlighting the zoonotic potential of this strain. Our results underscore the epidemiological importance of studying swine IAV in Latin America for epidemic and pandemic preparedness.