TY - JOUR T1 - An extended admixture pulse model reveals the limitations to Human-Neandertal introgression dating JF - bioRxiv DO - 10.1101/2021.04.04.438357 SP - 2021.04.04.438357 AU - Leonardo N. M. Iasi AU - Harald Ringbauer AU - Benjamin M. Peter Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/06/11/2021.04.04.438357.abstract N2 - Neandertal DNA makes up 2-3% of the genomes of all non-African individuals. The patterns of Neandertal ancestry in modern humans have been used to estimate that this is the result of gene flow that occurred during the expansion of modern humans into Eurasia, but the precise dates of this event remain largely unknown. Here, we introduce an extended admixture pulse model that allows joint estimation of the timing and duration of gene flow. This model leads to simple expressions for both the admixture segment distribution and the decay curve of ancestry linkage disequilibrium, and we show that these two statistics are closely related. In simulations, we find that estimates of the mean time of admixture are largely robust to details in gene flow models, but that the duration of the gene flow can only be recovered if gene flow is very recent and the exact recombination map is known. These results imply that gene flow from Neandertals into modern humans could have happened over hundreds of generations. Ancient genomes from the time around the admixture event are thus likely required to resolve the question when, where, and for how long humans and Neandertals interacted.Competing Interest StatementThe authors have declared no competing interest. ER -