RT Journal Article
SR Electronic
T1 Zinc<sup>2+</sup> ion inhibits SARS-CoV-2 main protease and viral replication <em>in vitro</em>
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.06.15.448551
DO 10.1101/2021.06.15.448551
A1 Love Panchariya
A1 Wajahat Ali Khan
A1 Shobhan Kuila
A1 Kirtishila Sonkar
A1 Sibasis Sahoo
A1 Archita Ghoshal
A1 Ankit Kumar
A1 Dileep Kumar Verma
A1 Abdul Hasan
A1 Shubhashis Das
A1 Jitendra K Thakur
A1 Rajkumar Halder
A1 Sujatha Sunil
A1 Arulandu Arockiasamy
YR 2021
UL http://biorxiv.org/content/early/2021/06/15/2021.06.15.448551.abstract
AB Zinc deficiency is linked to poor prognosis in COVID-19 patients while clinical trials with Zinc demonstrate better clinical outcome. The molecular target and mechanistic details of anti-coronaviral (SARS-CoV2) activity of Zinc remain obscure. We show that ionic Zinc not only inhibits SARS-CoV-2 main protease (Mpro) with nanomolar affinity, but also viral replication. We present the first crystal structure of Mpro-Zinc2+ complex at 1.9 Å and provide the structural basis of viral replication inhibition.Competing Interest StatementThe authors have declared no competing interest.